| NCT02495545 | Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury | St. Joseph's Hospital and Medical Center, Phoenix | | - Age 18 - 75 yrs
- Level C4-C8
AIS A, B, C- ≤ 24 hours
- NOT have penetrating injury, e.g. gunshot or knife wound
| Ended | 15 | NA | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Pain Numeric Rating Scale (NRS)
- Spinal Cord Independence Measure (SCIM)
| 180 days | 01 October 2015 | 13 July 2015 | 3 | |
| NCT02490501 | Safety and Efficacy of SC0806 (Fibroblast Growth Factor 1 and a Device) in Traumatic Spinal Cord Injury Subjects | BioArctic AB | | - Age 18 - 65 yrs
- Level T2-T11
AIS A- 4 months - 10 years
- have a BMI of less than 35.
- have a body height of less than 195cm (<6’4 feet).
- have a body weight of less than 125kg (<275 lbs).
- be able to undergo and tolerate the MRI scanning.
- NOT have known hypersensitivity to FGF1 or heparin
| Ended | 10 | PHASE1, PHASE2 | Biological/cell based | Standing/walking/mobility | - Adverse Events (AEs)
- Motor Evoked Potentials (MEPs)
| 18 months | 01 June 2015 | 03 July 2015 | 1 | |
| NCT02469675 | Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS | Bronx VA Medical Center | | - Age 21 - 65 yrs
- Level C2-C8
AIS B, C, D- ≥ 1 years
- have some weakness in the fingers of one hand.
- NOT have other implanted electrical device, e.g. pacemaker
| Ended | 39 | NA | Technology | Arm/hand function | - Motor Evoked Potentials (MEPs)
- Nerve Conduction Studies (compound motor action potentials - cMAP, sensory action potentials- SNAP, f-wave, H reflex)
| 0 days | 01 June 2015 | 11 June 2015 | 2 | |
| NCT02451683 | Corticospinal Function After Spinal Cord Injury | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-C8
AIS A, B, C, D- ≥ 6 months
- have some sensation spared in the hands at the C6, C7, and C8 dermatomes
- be able to reach and grasp a small object at least 8 cm in front without leaning forward.
| Ended | 120 | NA | Technology | Arm/hand function | | 5 months | 12 October 2020 | 22 May 2015 | 1 | |
| NCT02446210 | Neuroplasticity After Spinal Cord Injury | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-L2
AIS B, C- ≥ 1 months
- be able to grip with both hands and pick up a small object (e.g. a large paperclip) from a table, on own.
- must be able to bend elbow, leg, and foot, to some extent.
- must be able to take a few steps with or without help.
- NOT have other implanted device, e.g. pacemaker
| | 514 | NA | Technology | General health | | 5 months | 28 January 2021 | 18 May 2015 | 1 | |
| NCT02354625 | The Safety of ahSC in Chronic SCI With Rehabilitation | University of Miami | | - Age 18 - 65 yrs
- Level C5-T12
AIS A, B, C- ≥ 12 months
- be able to undergo an MRI.
- have a Body Mass Index (BMI) less than 35
| Ended | 8 | PHASE1 | Biological/cell based | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 2 Minute Walk Test
- American Spinal Injury Association Impairment Scale (AIS)
- Ashworth and Modified Ashworth Scale (MAS)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Motor Evoked Potentials (MEPs)
- Neuropathoc Pain Symptom Inventory (NPSI)
- Pendulum Test (Wartenberg)
- Quantitative Sensory Testing (QST)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Independence Measure (SCIM)
- Sympathetic skin response
- Timed Up and Go Test (TUG)
| 6 months | 01 January 2015 | 03 February 2015 | 1 | |
