| NCT06677229 | Phase 1b/2a Clinical Trial to Determine the Safety, Tolerability and Efficacy of TZ-161 in Spinal Cord Injury | Technophage, SA | | - Age 18 - 65 yrs
- Level T1-T12
AIS B, C, D- ≤ 24 null
| Recruiting | 28 | PHASE1, PHASE2 | Drug | General health | | 6 months | 01 August 2025 | 06 November 2024 | 2 | |
| NCT06494059 | A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients | University of Miami | | - Age 18 - 70 yrs
- Level C1-T10
AIS A, B, C, D- ≥ 6 months
- NOT have metal implants near stimulation sites (e.g., head or spine), implantable devices (e.g., cochlear implants, neurostimulators such as DBS or VNS), or cardiac devices (e.g., pacemakers or intracardiac lines)
- NOT have a traumatic brain injury, stroke, multiple sclerosis, or other disorders that could affect neuromotor function
- NOT have a history of epilepsy, convulsion or seizures
| Recruiting | 25 | NA | Technology | General health | - Motor Evoked Potentials (MEPs)
- Nine Hole Peg Test
| 2 months | 04 November 2024 | 10 July 2024 | 1 | |
| NCT06521723 | Low Oxygen Therapy to Enhance Walking Recovery After SCI. | Spaulding Rehabilitation Hospital | | - Age 18 - 80 yrs
- Level C1-L2
AIS C, D- ≥ 1 years
- be able to complete the 10-meter walk test without support from another person
- NOT have an active implanted devices (e.g., intrathecal baclofen pump)
| Recruiting | 60 | NA | Drug | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Blood Pressure and Heart Rate Regulation
- Neurogenic Bladder Symptom Score
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- Numeric Pain Rating Scale
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Injury Functional Ambulation Inventory (SCI-FAI)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 14 weeks | 06 June 2025 | 26 July 2024 | 2 | |
| NCT06248476 | Intermittent Theta Burst Stimulation and Repetitive Transcranial Magnetic Stimulation Combined With Robotic Rehabilitation on Ambulation in Spinal Cord Injury Patients | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | | - Age 18 - 45 yrs
- Level C1-S5
AIS C, D- ≥ 12 months
- NOT have epileptic seizures
- NOT have a metalic implant in brain or scalp
- NOT have a pacemaker
- Be able to walk at least 10 meters independently or with canadian, walker or walking stick
| Ended | 30 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Motor Evoked Potentials (MEPs)
- Spinal Cord Independence Measure (SCIM)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 6 weeks | 01 March 2023 | 08 February 2024 | 2 | |
| NCT06672458 | Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI) | University of Miami | | - Age 18 - 70 yrs
- Level C1-T1
AIS A, B, C, D- All
- NOT have an implanted neurostimulator, e.g., deep brain stimulation (DBS), epidural/subdural, vagal nerve stimulation (VNS)
- NOT have a cardiac pacemaker or intracardiac lines
| Recruiting | 60 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Manual Muscle Test (MMT)
- Nine Hole Peg Test
- Surface Electromyography (sEMG)
| 12 weeks | 01 November 2024 | 04 November 2024 | 1 | |
| NCT06611748 | Restoration of Hand Function in Cervical SCI | MetroHealth Medical Center | | - Age ≥ 18 yrs
- Level C1-C7
AIS A, B, C- ≥ 6 months
- NOT have an active implantable medical device such as a pacemaker or defibrillator
| Recruiting | 20 | NA | Technology | Arm/hand function | - Grasp and Release Test (GRT)
| 1 year | 01 January 2025 | 25 September 2024 | 1 | |
