| NCT06643312 | TPAD for Recovery of Standing After Severe SCI | Kessler Foundation | | - Age ≥ 18 yrs
- Level C1-T10
AIS A, B, C, D- ≥ 1 years
| Recruiting | 50 | NA | Rehabilitation | Standing/walking/mobility | - Neuromuscular Recovery Scale
- Surface Electromyography (sEMG)
| 6 months | 22 October 2024 | 16 October 2024 | 1 | |
| NCT06540859 | Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI | University of Washington | | - Age 21 - 65 yrs
- Level C1-T6
AIS A, B, C, D- ≤ 4 months
- NOT have pacemakers, stimulators, medication pumps in the trunk, deep brain stimulators, metallic devices in the head such as aneurysm clips/coils and stents, vagus nerve stimulators.
- NOT have a history of seizures.
| Recruiting | 26 | NA | Technology | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Blood Pressure and Heart Rate Regulation
- International Standards to Autonomic Function after SCI (ISAFSCI)
- Neurogenic Bladder Symptom Score
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- Numeric Pain Rating Scale
| 6 months | 01 December 2024 | 06 August 2024 | 1 | |
| NCT06564714 | Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | | - Age ≥ 18 yrs
- Level C1-L1
AIS A, B, C, D- ≤ 1 months
- NOT have pre-existing neurological disorders (cerebrovascular disease, Parkinson's disease, multiple sclerosis, etc.)
- NOT have a penetrating traumatic SCI
| Recruiting soon | 55 | PHASE4 | Drug | Arm/hand function | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Penn Spasm Frequency Scale (PSFS)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Independence Measure (SCIM)
| 6 months | 01 December 2024 | 21 August 2024 | 1 | |
| NCT06538974 | Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population | Wandercraft | | - Age ≥ 18 yrs
- Level C1-S5
AIS - All
| Recruiting | 100 | NA | Rehabilitation | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Adverse Events (AEs)
- Functional Independence Measure (FIM)
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- System Usability Scale (SUS)
- Timed Up and Go Test (TUG)
| 2 years | 16 February 2023 | 06 August 2024 | 1 | |
| NCT06690372 | Improving Heart Health in Individuals With SCI Using Home-Based Virtual Gaming | Drexel University | | - Age ≥ 18 yrs
- Level C1-S5
AIS A, B, C, D- All
- be wheelchair users (at least 75% of community mobility)
| Recruiting soon | 16 | NA | Rehabilitation | General health | - Blood Pressure and Heart Rate Regulation
- Brief Pain Inventory (BPI)
- Exercise Self-Efficacy Scale (ESES)
- Feasibility
- Pain Numeric Rating Scale (NRS)
- Patient Health Questionnaire-9 (PHQ-9)
| 16 weeks | 01 December 2025 | 15 November 2024 | 1 | |
| NCT06698224 | Paired Spinal Cord and Peripheral Nerve Stimulation to Recover Hand Function in SCI | Kessler Foundation | | - Age ≥ 18 yrs
- Level C1-T1
AIS - ≥ 6 months
- NOT have metal implant in the head
- NOT have a cardiac pacemaker
- NOT have an implanted brain stimulator
- NOT have an implanted pump (e.g., baclofen pump or pain pump)
| Recruiting soon | 14 | NA | Rehabilitation | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Motor Evoked Potentials (MEPs)
- Pain Numeric Rating Scale (NRS)
- Surface Electromyography (sEMG)
| 4 weeks | 02 January 2025 | 20 November 2024 | 1 | |
