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NCTID	Brief title	Sponsor	Design	Criteria	Status	Target enrollment	Study phase & design	Primary intervention type	Primary potential benefit	Outcome measure	Follow up	Start date	First posted	Location
NCT06828653	Comparing Digitally and Traditionally Made Ankle Foot Orthoses	Holland Bloorview Kids Rehabilitation Hospital		Age ≥ 8 yrs Level C1-S5 AIS All Require the use of an AFO to improve physical functioning Be able to ambulate independently Meet requirements for AFO funding by the Assistive Device Program in Ontario, Canada	Recruiting	50	NA	Technology	Standing/walking/mobility	10 Meter Walking Test (10 MWT) Goal Attainment Scaling (GAS) score Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) Timed Up and Go Test (TUG)	14 weeks	05 September 2025	14 February 2025	2
NCT06873776	Arm and Leg Cycling for Accelerated SCI Recovery	Shirley Ryan AbilityLab		Age 18 - 75 yrs Level C1-T11 AIS C, D ≥ 1 years Be able to ambulate independently for at least 10 meters Ambulate with maximum walking speed of less than 0.8 meters/second Have bilateral arm strength to independently arm cycle 15 minutes	By invitation	40	NA	Rehabilitation	Standing/walking/mobility	10 Meter Walking Test (10 MWT) 6-Minute Walk Test (6MWT) Ashworth and Modified Ashworth Scale (MAS) Berg Balance Scale (BBS) Motor Evoked Potentials (MEPs) Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs) Surface Electromyography (sEMG) Walking Index for Spinal Cord Injury (WISCI) and WISCI II	6 months	01 December 2025	13 March 2025	1
NCT06922890	First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury	Yonsei University		Age 19 - 60 yrs Level C1-S5 AIS A, B ≥ 6 months Be able to undergo general anesthesia Be able to provide evidence of non-fertile status, if female NOT have significant contraindications for elective surgery NOT have a history of malignancy within the previous 5 years	Recruiting	9	PHASE1, PHASE2	Drug	General health	Adverse Events (AEs)	7 months	30 July 2025	11 April 2025	2
NCT06978205	Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury	Qilu Hospital of Shandong University		Age 18 - 80 yrs Level C1-S5 AIS All Have urinary retention with post-void residual volume more than 300ml Have urodynamic evidence of maximal urethral pressure >50cmH2O NOT use an indwelling urinary catherter for bladder management NOT have a urinary tract infection	Recruiting	74	NA	Technology	Bladder health/function	Hospital Anxiety and Depression Scale (HADS) Neurogenic Bladder Symptom Score Qualiveen	3 weeks	28 April 2025	18 May 2025	1
NCT07019207	Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation	Istinye University		Age 18 - 60 yrs Level T1-S5 AIS ≥ 3 months Have active shoulder flexion and abduction of at least 90 degrees Be able to sit in a chair for at least 30 minutes NOT have musculoskeletal pain >5 out of 10 on the Visual Analog Scale NOT have a history of significant head trauma	Recruiting soon	45	NA	Rehabilitation	General health	Canadian Occupational Performance Measure Fugl-Meyer Assessment (FMA) Hand-Held Myometery / Dynamometry Modified Functional Reach Test (mFRT)	6 weeks	16 June 2025	13 June 2025	2
NCT07137780	Lokomat® vs RoboGait® Under Different Guidance Force Settings in Motor-Incomplete SCI	Ankara City Hospital Bilkent		Age ≥ 18 yrs Level T3-S5 AIS C, D ≥ 2 years NOT have implanted electronic devices NOT have a colostomy	Ended	19	NA	Rehabilitation	Standing/walking/mobility	American Spinal Injury Association Impairment Scale (AIS) Berg Balance Scale (BBS) International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) Spinal Cord Independence Measure (SCIM) Timed Up and Go Test (TUG) Walking Index for Spinal Cord Injury (WISCI) and WISCI II World Health Organization Quality of Life- BREF (WHOQOL-BREF)	2 years	23 November 2022	22 August 2025	2