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Double Dose 4-AP on Functional Recovery After Spinal Cord Injury

Drug
General health
Online since 15 October 2025, updated 56 days ago
Curated trial

About this trial

This trial is enrolling 27 individuals with chronic spinal cord injury to test the effect of Dalfampridine (4-AP) in combination with electrical stimulation and walking training. 4-AP is a potassium channel blocker that may enhance nerve signals. If included, participants will be randomly assigned to receive 40 sessions of either 4-AP or a placebo (taken twice daily), along with stimulation to the spinal cord and peripheral nerves, combined with walking training. Final testing will be performed after 12 weeks. .

Included participants

Gender
All
Age
18 - 85 years
Injury level
C1 - L2
  • Severity (AIS)?
    • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 6 months
    Healthy volunteers
    No
    C1-L2
    Additionally, participants must
    NOT have a metal plate in the skull
    NOT have scalp shrapnel, cochlear implants, or aneurysm clips

    What’s involved

    Type

    Drug

    Details

    - Participants will be randomly assigned to receive either Dalfampridine (4-AP) or a placebo twice daily, along with 40 sessions of stimulation to the spinal cord and peripheral nerves, combined with walking training. - 4-AP is a potassium channel blocker that may enhance nerve signals. - Final testing will be performed after 12 weeks.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Bladder health/function

    Bowel health

    Mental health and psychosocial factors

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Feb 2025
    • Organisation
    • Shirley Ryan AbilityLab
    View on clinicaltrials.gov
    for more details
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Feb 2025
    • Organisation
    • Shirley Ryan AbilityLab
    View on clinicaltrials.gov
    for more details

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    Proudly supported by

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