| NCT06410001 | CE-STAND: Cervical Epidural STimulation After Neurologic Damage | University of Minnesota | | - Age ≥ 22 yrs
- Level C4-C7
AIS A, B- ≥ 1 years
| Recruiting soon | 36 | PHASE1, PHASE2 | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Blood Pressure and Heart Rate Regulation
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Surface Electromyography (sEMG)
| 1 year | 01 March 2026 | 10 May 2024 | 1 | |
| NCT06375759 | Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia | Xuanwu Hospital, Beijing | Parallel Assignment | - Age 18 - 80 yrs
- Level C1-S5
AIS - All
- Have a syringomyelia documented with MRI
| Recruiting | 200 | Not Applicable | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
| 2 years | 01 April 2024 | 19 April 2024 | 1 | |
| NCT06438991 | Spinal Cord Stimulation for Lower Extremity Function | Brigham and Women's Hospital | | - Age 18 - 65 yrs
- Level C6-T10
AIS B, C- ≥ 12 months
| Recruiting soon | 10 | NA | Technology | Standing/walking/mobility | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 6 months | 01 July 2024 | 03 June 2024 | 0 | |
| NCT06406855 | Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI) | University of Miami | | - Age 21 - 70 yrs
- Level C1-T10
AIS B, C, D- ≥ 6 months
- NOT have traumatic brain injury, stroke, multiple sclerosis, or other neuromuscular disorders that could affect neuromotor function and walking.
- NOT have metal implants in their head
- walk overground for at least 10 meters with some assistance of a therapist and minimal body-weight support
| Recruiting | 12 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Berg Balance Scale (BBS)
- Reintegration to Normal Living (RNL) Index
- Spinal Cord Independence Measure (SCIM)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 6 months | 07 May 2024 | 09 May 2024 | 1 | |
| NCT06351852 | Transdermal Administration by a Novel Wireless Iontophoresis Device | James J. Peters Veterans Affairs Medical Center | | - Age 18 - 89 yrs
- Level C1-S5
AIS - All
- NOT have a deep brain stimulation device
- NOT have a history of bowel or bladder obstruction
- NOT have a history of heart conditions including coronary artery disease, myocardial infarctions, or arrhythmias
| Ended | 2 | EARLY_PHASE1 | Drug | Bowel health | - Bristol Stool Form Scale (BSFS)
| 3 days | 22 March 2022 | 08 April 2024 | 2 | |
| NCT05492188 | Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI | Medical University of South Carolina | | - Age ≥ 18 yrs
- Level C1-S5
AIS - ≥ 1 years
- have neuropathic pain in lower leg
- NOT have peripheral neuropathy
- NOT have motoneuron injury
| Recruiting | 15 | NA | Technology | Pain | - Functional Independence Measure (FIM)
- Neuropathoc Pain Symptom Inventory (NPSI)
- Quantitative Sensory Testing (QST)
- Spinal Cord Independence Measure (SCIM)
| 3 months | 27 March 2023 | 08 August 2022 | 1 | |
