| NCT06440538 | Rebuilding Inter-limb Transfer in Cervical SCI | The Cleveland Clinic | | - Age 18 - 75 yrs
- Level C4-C8
AIS C, D- ≥ 1 years
- NOT have a history of other neurological conditions such as stroke, Parkinson's, and traumatic brain injury (TBI)
- NOT have a pacemaker, metal in the skull, seizure history.
| Recruiting | 17 | EARLY_PHASE1 | Technology | General health | - Motor Evoked Potentials (MEPs)
- Nerve Conduction Studies (compound motor action potentials - cMAP, sensory action potentials- SNAP, f-wave, H reflex)
- Nine Hole Peg Test
| 0 days | 15 February 2024 | 04 June 2024 | 1 | |
| NCT06421753 | Efficiency of Spatially Distributed Sequential Stimulation (Sdss) for Functional Electrical Stimulation (FES) of Upper Motor Neuron Syndrome (UMR) Patients | UGECAM Rhône-Alpes | | - Age 18 - 80 yrs
- Level C1-S5
AIS - All
- have motor deficit due to an acquired traumatic or neurodegenerative motor deficiency
| Ended | 10 | NA | Rehabilitation | Standing/walking/mobility | | 12 days | 16 May 2024 | 20 May 2024 | 2 | |
| NCT06379711 | Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury | University of British Columbia | | - Age 19 - 65 yrs
- Level C1-T10
AIS A, B- ≥ 1 years
- NOT have any implanted metal (dental implants, pacemakers, stimulators, or medication pumps)
- NOT have an intrathecal baclofen pump.
| Recruiting soon | 22 | NA | Technology | General health | | 8 weeks | 01 August 2024 | 23 April 2024 | 1 | |
| NCT05954715 | Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury | Loughborough University | | - Age 18 - 70 yrs
- Level C1-S5
AIS A, B, C, D- ≥ 1 years
| | 40 | NA | Drug | Arm/hand function | - Feasibility
- Manual Muscle Test (MMT)
| 1 year | 01 November 2023 | 20 July 2023 | 0 | |
| NCT03053791 | Deep Brain Stimulation in Patients With Incomplete Spinal Cord Injury for Improvement of Gait | University of Zurich | | - Age 18 - 75 yrs
- Level C1-T10
AIS C, D- 3 months - 2 years
| Recruiting | 5 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Epworth Sleepiness Scale (ESS)
- Fatigue Severity Scale (FSS)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Independence Measure (SCIM)
- Surface Electromyography (sEMG)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 6 months | 15 March 2018 | 15 February 2017 | 1 | |
| NCT06308367 | The Therapeutic Effect of Betaine in Syringomyelia | Xuanwu Hospital, Beijing | Parallel Assignment | - Age 18 - 80 yrs
- Level C1-S5
AIS - All
- NOT have transplanted organs
- NOT have a history of psychiatric diseases or seizures
- NOT have a history of cardiovascular disease
| Recruiting | 30 | Phase 2 | Drug | Arm/hand function | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Pain Visual Analog Scale (VAS)
| 3 months | 01 March 2024 | 13 March 2024 | 1 | |
