| NCT03922802 | SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training | Shirley Ryan AbilityLab | | - Age ≥ 18 yrs
- Level C3-S5
AIS A, B, C, D- ≥ 6 months
- must not be currently receiving regular physical therapy services.
- must not have epilepsy or a concussion within 6 months.
- NOT have implanted device, e.g. pacemaker or drug pump
- NOT be dependent on ventilator
| Ended | 14 | NA | Technology | Standing/walking/mobility | | | 01 December 2020 | 22 April 2019 | 1 | |
| NCT03811301 | [BrainConnexion] - Neurodevice Phase I Trial | National Neuroscience Institute | | - Age 21 - 70 yrs
- Level C1-C8
AIS A, B, C, D- ≤ 70 years
- NOT have history of epilepsy or seizures
- be able to perform pre-operation Brain Computer Interface training
| | 5 | NA | Technology | Arm/hand function | | | 21 November 2017 | 22 January 2019 | 1 | |
| NCT03806023 | EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals | Bronx VA Medical Center | | - Age 18 - 75 yrs
- Level C2-C8
AIS C, D- 1 years - 75 years
- be able to perform thumb-middle finger opposition pinch task.
- have at least some detectable muscle innervation and function in the small muscle at the base of the thumb (abductor pollicis brevis) on at least one side.
- NOT be dependent on ventilator
- NOT have implanted device, e.g. pacemaker
| Ended | 8 | NA | Technology | Arm/hand function | | | 01 February 2018 | 16 January 2019 | 2 | |
| NCT03780829 | AIH for Spinal Cord Repair | VA Office of Research and Development | | - Age 18 - 80 yrs
- Level C1-C8
AIS A, B, C, D- 1 years - 99 years
- have impaired sensation and strength in the hands, but able to grasp small objects with one hand and able to grasp between the index finger and thumb
- be right handed
- NOT have a pacemaker
| Recruiting | 90 | EARLY_PHASE1 | Drug | Arm/hand function | | | 25 February 2020 | 19 December 2018 | 1 | |
| NCT03774043 | Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI | Shirley Ryan AbilityLab | | - Age 18 - 70 yrs
- Level C3-T1
AIS C, D- 6 months - 70 years
- NOT have an anti-spasticity drug injection within 3 months of treatment
| | 24 | PHASE1, PHASE2 | Drug | Arm/hand function | | | 01 May 2016 | 12 December 2018 | 1 | |
| NCT03762655 | Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care | InVivo Therapeutics | | - Age 16 - 70 yrs
- Level T2-T12
AIS A- ≤ 7 days
- have a non-penetrating SCI (contusion or crush type of SCI).
| Ended | 20 | NA | Surgery | General health | | | 21 May 2019 | 04 December 2018 | 18 | |
