| NCT05095454 | Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI | Mayo Clinic | | - Age ≥ 22 yrs
- Level C1-T10
AIS A, B, C, D- ≥ 1 years
- NOT have a history of frequent, severe, autonomic dysreflexia.
- NOT have history of frequent hypotension or frequent hypertension.
- NOT be ventilator dependent
- have intact spinal reflexes below the level of injury
| Ended | 6 | NA | Technology | Standing/walking/mobility | - 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Electromyography
- Motor evoked potential
- Neurogenic Bladder Symptom Score
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET)
| 5 months | 04 March 2022 | 27 October 2021 | 1 | |
| NCT05094362 | Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning | Medical University of South Carolina | | - Age ≥ 18 yrs
- Level C1-T10
AIS B, C, D- ≥ 1 years
- • ability to ambulate at least 10 m with or without an assistive device within 100 seconds
- • have clinical signs of spasticity in the plantarflexor muscles (gas pedal movement).
- • NOT have a pre-existing or confounding neurological condition (e.g., history of Multiple Sclerosis, Traumatic Brain Injury, Stroke, Parkinson's disease)
- • NOT have a cardiac condition.
| Recruiting | 25 | NA | Rehabilitation | Spasticity | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Ashworth and Modified Ashworth Scale (MAS)
- Berg Balance Scale (BBS)
- Functional Independence Measure (FIM)
- H reflex
- Manual Muscle Test (MMT)
- Spinal Cord Independence Measure (SCIM)
- Tardieu Scale
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 3 months | 23 August 2023 | 26 October 2021 | 1 | |
| NCT05094752 | Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Spinal Cord Injury | Assistance Publique - Hôpitaux de Paris | | - Age ≥ 18 yrs
- Level C1-T6
AIS A, B, C, D- ≤ 10 days
| | 40 | NA | Technology | Spasticity | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Independence Measure (SCIM)
| 1 year | 20 October 2021 | 26 October 2021 | 1 | |
| NCT05041322 | Improving Ventilatory Capacity in Those With Chronic High Level SCI | Spaulding Rehabilitation Hospital | | - Age 18 - 50 yrs
- Level C1-T3
AIS A, B, C- ≥ 24 months
- able to perform arm crank exercise
- NOT have a heart disease (cardiomyopathy)
- NOT have high blood pressure (>140/90 mmHg or you are taking high blood pressure medication)
- NOT have an intrathecal baclofen pump implanted
- NOT regularly use tobacco
| Ended | 13 | PHASE2 | Drug | General health | | 14 days | 29 November 2020 | 13 September 2021 | 1 | |
| NCT04988425 | TNFα Monoclonal Antibody for Acute Spinal Cord Injury | Shanghai Changzheng Hospital | | - Age 18 - 60 yrs
- Level -
AIS A, B, C, D- ≤ 2 weeks
| | 90 | PHASE1, PHASE2 | Drug | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Motor evoked potential
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
| 12 months | 01 September 2022 | 03 August 2021 | 1 | |
| NCT04936620 | Duroplasty for Injured Cervical Spinal Cord With Uncontrolled Swelling | St George's, University of London | | - Age ≥ 16 yrs
- Level C2-T1
AIS A, B, C- ≤ 72 hours
- require surgery that includes laminectomy
| Recruiting | 222 | NA | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Hand-Held Myometery / Dynamometry
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 12 months | 08 October 2021 | 23 June 2021 | 32 | |
