Spinal Cord Injury Neuroprotection With Glyburide

Drug
General health
Online since 1 November 2022, updated 482 days ago

About this trial

This trial is enrolling individuals with acute cervical or thoracic spinal cord injuries to test the feasibility, safety and efficacy of a drug (Glyburide/DiaBeta). Investigators want to see if they can recruit participants within 8 hours of spinal cord injury (in preparation for a larger study), assess drug safety and determine if drug can help lessen further damage (neuroprotection) following acute spinal cord injury. If included, participants will receive 12 oral doses of Glyburide (every 6 hours) over 3 days starting within 8 hours of spinal cord injury. Final testing will be performed after 1 year.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C2 - T12
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≤ 8 null
  • Injury type
  • Traumatic

    Healthy volunteers
    Yes
    C2-T12

    What’s involved

    Type

    Drug

    Details

    - participants will receive 12 doses of Glyburide over 3 days (every 6 hours) - the total daily dose of Glyburide will be 3.125mg on day 1 and 2.5mg on days 2 and 3 - Final testing of neurological function will be performed after 1 year

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 7 Jul 2022
    • Organisation
    • University of Kentucky
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 7 Jul 2022
    • Organisation
    • University of Kentucky

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more