Spinal Cord Injury Neuroprotection With Glyburide
About this trial
This trial is enrolling individuals with acute cervical or thoracic spinal cord injuries to test the feasibility, safety and efficacy of a drug (Glyburide/DiaBeta). Investigators want to see if they can recruit participants within 8 hours of spinal cord injury (in preparation for a larger study), assess drug safety and determine if drug can help lessen further damage (neuroprotection) following acute spinal cord injury. If included, participants will receive 12 oral doses of Glyburide (every 6 hours) over 3 days starting within 8 hours of spinal cord injury. Final testing will be performed after 1 year.
Included participants
Traumatic
What’s involved
Type
Details
- participants will receive 12 doses of Glyburide over 3 days (every 6 hours) - the total daily dose of Glyburide will be 3.125mg on day 1 and 2.5mg on days 2 and 3 - Final testing of neurological function will be performed after 1 year
Potential benefits
Main benefits
General health
Additional benefits
Arm/hand function
Sensory function
Standing/walking/mobility
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting
- Trial start date
- 7 Jul 2022
- Organisation
- University of Kentucky
- Trial recruitment status
- Recruiting
- Trial start date
- 7 Jul 2022
- Organisation
- University of Kentucky
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more