| NCT05217498 | Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury | Spaulding Rehabilitation Hospital | | - Age 18 - 75 yrs
- Level C2-T12
AIS C, D- ≥ 12 months
- have the ability to advance one step overground without human assistance
| Recruiting soon | 40 | PHASE1, PHASE2 | Drug | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Timed Up and Go Test (TUG)
| 20 days | 01 September 2027 | 01 February 2022 | 1 | |
| NCT05333770 | Repetitive Transcranial Magnetic Stimulation to Promote Regeneration in Persons With SCI | Kessler Foundation | | - Age 18 - 55 yrs
- Level C2-C6
AIS A, B, C, D- All
- NOT have metal in the skull
- NOT have a pacemaker
- NOT have a history or seizures or brain injury
| | 20 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
| 6 months | 20 August 2022 | 19 April 2022 | 1 | |
| NCT05643313 | Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments | ABLE Human Motion S.L. | | - Age 18 - 70 yrs
- Level C5-L5
AIS A, B, C, D- ≥ 6 months
| Ended | 10 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0)
- Spinal Cord Independence Measure (SCIM)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
- World Health Organization Quality of Life- BREF (WHOQOL-BREF)
| 11 weeks | 25 November 2022 | 08 December 2022 | 2 | |
| NCT05700942 | AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI | University of Florida | | - Age 18 - 65 yrs
- Level C1-T12
AIS C, D- ≥ 1 years
- be able to walk 3 meters with or without devices, braces, or assistance of one person
- NOT have diagnosis of other neurologic condition
| Active | 30 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- H reflex
| 8 weeks | 10 March 2023 | 26 January 2023 | 1 | |
| NCT03567213 | Investigation on the Cortical Communication (CortiCom) System | Johns Hopkins University | Single Group Assignment | - Age 22 - 70 yrs
- Level C1-C8
AIS A, B, C, D- ≥ 1 years
- NOT have implanted devices incompatible with MRI
| Recruiting | 3 | Not Applicable | Surgery | General health | | 26 weeks | 14 December 2021 | 25 June 2018 | 1 | |
| NCT05622994 | Effects of CB1 Antagonist/Reverse Agonist Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury | Hospital Nacional de Parapléjicos de Toledo | | - Age 18 - 75 yrs
- Level C4-L1
AIS C, D- ≥ 1 years
- NOT have severe bone, kidney, or liver dysfunction
- NOT have hypothyroidism
| | 80 | PHASE2 | Drug | General health | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Ashworth and Modified Ashworth Scale (MAS)
- European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L)
- Fatigue Severity Scale (FSS)
- Hospital Anxiety and Depression Scale (HADS)
- Numeric Pain Rating Scale
- Penn Spasm Frequency Scale (PSFS)
- Spinal Cord Independence Measure (SCIM)
| 120 days | 01 November 2022 | 21 November 2022 | 1 | |
