| NCT06723561 | Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury | Medical College of Wisconsin | | - Age ≥ 18 yrs
- Level C1-T12
AIS - ≥ 6 months
- experience central neuropathic pain, based on evaluation by a Physical medicine and rehabilitation physician
| Recruiting | 10 | PHASE2 | Drug | Mental health and psychosocial factors | - Neuropathoc Pain Symptom Inventory (NPSI)
- Quality of Life Index (QLI) - SCI Version
| 12 weeks | 01 February 2025 | 09 December 2024 | 1 | |
| NCT06838637 | Transcutaneous Spinal Cord Stimulation Home Study | University of British Columbia | | - Age 19 - 70 yrs
- Level C1-T6
AIS A, B- ≥ 1 years
- NOT have an intrathecal baclofen pump
- NOT have any implanted metal (other than dental implants) in the skull or presence of pacemakers, stimulators, or medication pumps in the trunk
- NOT have undergone electrode implantation surgery
| Recruiting | 6 | NA | Technology | General health | - Adverse Events (AEs)
- Blood Pressure and Heart Rate Regulation
- Surface Electromyography (sEMG)
| 10 weeks | 15 February 2024 | 20 February 2025 | 1 | |
| NCT06853015 | Double Dose 4-AP on Functional Recovery After Spinal Cord Injury | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-L2
AIS A, B, C, D- ≥ 6 months
- NOT have a metal plate in the skull
- NOT have scalp shrapnel, cochlear implants, or aneurysm clips
| Recruiting | 27 | PHASE1, PHASE2 | Drug | General health | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Electrical perceptual threshold
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- SCI- QOL Bladder Management Difficulties
- SCI-QOL Bowel Management Difficulties
| 12 weeks | 01 February 2025 | 28 February 2025 | 1 | |
| NCT06700304 | CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices | Neuralink Corp | | - Age ≥ 19 yrs
- Level C1-T1
AIS B- ≥ 12 months
- NOT have an active implanted devices
- Not require an MRI during the study
| Recruiting | 6 | NA | Technology | General health | - Adverse Events (AEs)
- Generalized Anxiety Disorder (GAD-7)
- Patient Health Questionnaire-9 (PHQ-9)
| 6 years | 20 November 2024 | 21 November 2024 | 1 | |
| NCT07164846 | Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait | Brooks Rehabilitation | | - Age ≥ 18 yrs
- Level C1-S5
AIS - All
- NOT have implanted medical devices, a pacemaker, or defibrillator
- NOT have an implanted stimulator or pump that cannot be turned off externally
| Recruiting | 30 | NA | Rehabilitation | Standing/walking/mobility | - 6-Minute Walk Test (6MWT)
- Blood Pressure and Heart Rate Regulation
| 4 weeks | 05 August 2025 | 10 September 2025 | 2 | |
| NCT07165353 | Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI | Swiss Paraplegic Research, Nottwil | | - Age 18 - 75 yrs
- Level C1-S5
AIS A, B, C, D- ≥ 6 months
| Recruiting soon | 40 | NA | Rehabilitation | Pain | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Depression Anxiety Stress Scale-21 (DASS-21)
- Neuropathoc Pain Symptom Inventory (NPSI)
- Pain Numeric Rating Scale (NRS)
| 15 weeks | 01 December 2025 | 10 September 2025 | 1 | |
