| NCT02673320 | Prospective Study for Delay in Surgical Treatment of Traumatic Cervical Central Cord Injury in Canal Stenosis | Nantes University Hospital | Parallel Assignment | - Age ≥ 18 yrs
- Level C1-T1
AIS A, B, C, D- ≤ 15 days
- have an acute spinal cord injury capable of undergoing surgical decompression within 48 hours at the time of randomization.
- have a neurological level of injury between C2-T1
- have one of the following ASIA impairment scale (AIS):
- AIS A: complete; no feeling or movement below the injury
- AIS B: incomplete; have some feeling, but no movement, below the injury
- AIS C: incomplete; at least some feeling and mostly weak movement below the injury
- AIS D: incomplete; at least some feeling and, some weak but mostly stronger movement below the injury
- be at least 18 years of age
- be able to undergo an MRI
| Recruiting | 72 | Not Applicable | Surgery | Standing/walking/mobility | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Pain Visual Analog Scale (VAS)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 2 years | 01 July 2016 | 03 February 2016 | 8 | |
| NCT02611375 | Conditioning Neural Circuits to Improve Upper Extremity Function | Shepherd Center, Atlanta GA | | - Age 18 - 65 yrs
- Level C1-C8
AIS A, B, C, D- All
- must have some trouble moving at least one of your arms/hands.
- must be able to pick up an object with at least one hand without any type of help.
- be able to lift one arm up to chest level.
- NOT have other implanted device, e.g. pacemaker
- NOT have history of epilepsy or severe headaches
| Ended | 80 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Motor Evoked Potentials (MEPs)
- Surface Electromyography (sEMG)
| 6 weeks | 09 February 2017 | 20 November 2015 | 1 | |
| NCT02574585 | Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury | Hospital Sao Rafael | | - Age 18 - 65 yrs
- Level T1-L2
AIS A- ≥ 12 months
- NOT have diabetes mellitus type 1 or 2
- NOT have SCI due to sharp object or firearm
- NOT have other metallic implant that would affect MRI
| | 40 | PHASE2 | Biological/cell based | Standing/walking/mobility | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
| 12 months | 01 December 2019 | 14 October 2015 | 0 | |
| NCT02574572 | Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury | Hospital Sao Rafael | | - Age 18 - 65 yrs
- Level C5-C7
AIS A- ≥ 12 months
- have a spinal cord injury for at least 12 months
- have a neurological level of injury between C5 and C7
- have the following ASIA impairment scale (AIS) grade:
- AIS A: complete; no feeling or movement below the injury
- be between 18 and 65 years of age
- NOT have penetrating injury, e.g. gunshot or knife wound
- NOT have other device implanted that would affect MRI, e.g. pacemaker
| | 10 | PHASE1 | Biological/cell based | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
| 12 months | 06 September 2017 | 14 October 2015 | 1 | |
| NCT02566850 | Investigational Study of the Ekso for High-Dosage Use by Individuals With SCI in a Non-Clinical Environment | Ekso Bionics | | - Age 18 - 65 yrs
- Level C1-S5
AIS A, B, C, D- All
- have a body height between 152 and 193cm (5’-6’33 feet)
- have a body weight of less than 100kg (<200 lbs)
- have a prior experience or be willing to train on the Ekso device with a minimum of 20 hours and no more than 50 hours of device use and require no greater than minimal assist (support of up to 25% body weight) for safe and consistent walking. Participants with more than 50 hours of device experience must agree to a 1 month period of non-use prior to acquisition of baseline measures
| Ended | 4 | NA | Rehabilitation | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Bowel and bladder control
- Spinal Cord Independence Measure (SCIM)
| 42 months | 01 January 2014 | 02 October 2015 | 1 | |
| NCT02564419 | Brain Machine Interface (BMI) in Subjects Living With Quadriplegia | University of Miami | | - Age 22 - 50 yrs
- Level C5-C6
AIS A, B- ≥ 6 months
| Ended | 1 | NA | Technology | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
| 2 years | 01 November 2015 | 30 September 2015 | 1 | |
