| NCT02978638 | Electrical Stimulation for Continence After Spinal Cord Injury | Palo Alto Veterans Institute for Research | | - Age ≥ 22 yrs
- Level C5-S5
AIS A- ≥ 2 years
- NOT have other implanted device, e.g. pacemaker
| Active | 10 | NA | Technology | Bladder health/function | - Bowel and bladder control
| 12 months | 01 September 2014 | 01 December 2016 | 4 | |
| NCT02943915 | The WISE Trial - Walking Improvement for SCI With Exoskeleton | Ekso Bionics | | - Age 18 - 75 yrs
- Level C1-T10
AIS C, D- ≥ 6 months
| Ended | 45 | NA | Rehabilitation | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Berg Balance Scale (BBS)
- Timed Up and Go Test (TUG)
| 24 weeks | 01 September 2016 | 25 October 2016 | 10 | |
| NCT02917291 | Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury | Ferrer Internacional S.A. | | - Age 16 - 70 yrs
- Level T1-T12
AIS A, B- ≥ null hours
- have a spinal cord injury for less than 5 days (24-120h) when the surgery and treatment occurs.
- have a neurological level of injury between T1 and T12.
- have one of the following ASIA impairment scale (AIS):
- AIS A: complete; no feeling or movement below the injury.
- AIS B: incomplete; have some feeling, but no movement, below the injury.
- be between the ages of 18 and 65 years.
- NOT be ventilator dependent
- NOT have penetrating injury, e.g. gunshot
| | 48 | PHASE1, PHASE2 | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Feasibility
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Independence Measure (SCIM)
| 1 year | 01 December 2016 | 28 September 2016 | 10 | |
| NCT02899858 | Restoration of Standing and Walking With ISMS in Humans | Vanderbilt University Medical Center | | - Age 18 - 50 yrs
- Level T2-T8
AIS A- ≥ 1 years
- already be scheduled for routine spinal surgery in the region of T9-12.
- have the ability to travel to Nashville (Tennessee).
- NOT have other implanted device, e.g. pacemaker or stimulator
| Ended | 0 | NA | Technology | Standing/walking/mobility | | 3 years | 01 January 2015 | 14 September 2016 | 1 | |
| NCT02799966 | Recovery of Upper Limb Function in Persons With Spinal Cord Injury: Lead-In Study | University of British Columbia | | - Age ≥ 18 yrs
- Level C4-C7
AIS B, C, D- ≥ 10 days
- have had a spinal cord injury for at least 10 days.
- have a neurological injury level in the neck, between C4 and C7.
- ASIA impairment scale (AIS) is one of the following:
- AIS B: incomplete; have feeling, but no movement, below injury level
- AIS C: incomplete; at least some feeling and mostly weak movement below injury
- AIS D: incomplete; at least some feeling and, some weak but mostly stronger movement below injury
- be at least 18 years of age.
- NOT have other implanted device, e.g. pacemaker
| Ended | 9 | NA | Technology | Arm/hand function | - Action Research Arm Test (ARAT)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Spinal Cord Independence Measure (SCIM)
- Toronto Rehabilitation Institute Hand Function Test
| 7 weeks | 12 December 2017 | 15 June 2016 | 3 | |
| NCT02688049 | NeuroRegen Scaffold™ Combined With Stem Cells for Chronic Spinal Cord Injury Repair | Chinese Academy of Sciences | | - Age 18 - 65 yrs
- Level C5-T12
AIS A- All
- have a chronic spinal cord injury
- have a neurological level of injury between C5 and Th12
- have the following ASIA impairment scale (AIS) classifications:
- AIS A: complete; no feeling or movement below the injury with no evidence of further improvement.
- be between 18 and 65 years of age
- be able and willing to attend scheduled follow-up visits over 24 months at the study center (Tianjin, China).
| | 30 | PHASE1, PHASE2 | Biological/cell based | Arm/hand function | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Bowel and bladder control
- Functional Independence Measure (FIM)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
| 24 months | 01 January 2016 | 23 February 2016 | 1 | |
