| NCT05386537 | Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI | Kessler Foundation | | - Age 18 - 80 yrs
- Level -
AIS C, D- ≤ 3 months
- Be able to activate the muscles of the upper arm and forearm with enough strength as determined by the therapist.
- Have full passive range of motion of elbow, as determined by study staff
- NOT have excessive spasticity in elbow or wrist jointsas determined by study staff
- NOT have a history of neurologic disorder other than spinal spinal cord injury
- NOT have severe psychiatric problems
- NOT have a history of epilepsy, seizure, or convulsion
| | 20 | EARLY_PHASE1 | Rehabilitation | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Surface Electromyography (sEMG)
| 10 weeks | 01 April 2021 | 23 May 2022 | 1 | |
| NCT05411692 | Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury | Riphah International University | | - Age 15 - 50 yrs
- Level C6-C7
AIS D- ≤ 18 months
- HAVE voluntary wrist extension
| Ended | 26 | NA | Technology | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- Spinal Cord Independence Measure (SCIM)
| 6 weeks | 15 March 2022 | 09 June 2022 | 1 | |
| NCT05115149 | The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments. | Skolkovo Institute of Science and Technology | | - Age 18 - 60 yrs
- Level C3-C7
AIS A, B- ≥ 1 months
- NOT have severe cognitive impairments
- NOT have a concomitant disease which has resulted in decrease in muscle strength or increase in muscle tone
- NOT have a significant loss of joint range of motion
- NOT be taking muscle relaxant medication
- NOT have an implanted pacemaker or other implanted electronic device
| | 60 | NA | Technology | Arm/hand function | - Action Research Arm Test (ARAT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Rivermead Mobility Index (RMI)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
| 6 weeks | 01 October 2021 | 10 November 2021 | 12 | |
| NCT05284201 | LIFT Home Study of Non-Invasive ARC Therapy for Spinal Cord Injury | ONWARD Medical, Inc. | | - Age 22 - 75 yrs
- Level C2-C8
AIS B, C, D- ≥ 12 months
- have completed the Up-LIFT Study within the prior 12 months
- be indicated for upper extremity training procedures by treating physician, occupational therapist or physical therapist
| Ended | 17 | NA | Technology | General health | | 6 months | 03 March 2022 | 17 March 2022 | 5 | |
| NCT05462925 | Prediction of Muscle Responsiveness to FES Therapy | University Health Network, Toronto | | - Age ≥ 18 yrs
- Level C1-C8
AIS - ≥ 6 months
- tolerate being in a seated position for at least one hour
- NOT have previous history of any other neuromuscular disorder or conditions that may affect motor response
| Ended | 10 | NA | Technology | Arm/hand function | - Manual Muscle Test (MMT)
- Surface Electromyography (sEMG)
| 30 sessions are completed (6-10 weeks) | 20 July 2022 | 18 July 2022 | 1 | |
| NCT05447676 | Effects of 4-AP on Functional SCI Recovery | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-L2
AIS A, B, C, D- ≥ 4 weeks
- NO history of renal impairment
- NO debilitating disease prior to the SCI that caused exercise intolerance
- NO history of head injury or stroke
- NO history of seizure or epilepsy
- NO scalp shrapnel, cochlear implants, or aneurysm clips
- NO metal plate in skull
| | 44 | EARLY_PHASE1 | Drug | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Manual Muscle Test (MMT)
- Motor evoked potential
- SCI- QOL Bladder Management Difficulties
- SCI-QOL Bowel Management Difficulties
- Surface Electromyography (sEMG)
| 12 weeks | 30 June 2022 | 07 July 2022 | 1 | |
