Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

Technology
General health
Online since 4 September 2025, updated 7 days ago

About this trial

This feasibility trial is enrolling 5 participants with acute spinal cord injury (<50 days) to test the effect of transcutaneous spinal stimulation (tSS) on blood pressure. tSS is a non-invasive technique that uses skin surface electrodes to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will receive tSS at regular intervals during 20 to 29 sessions over the year. Final testing of cardiovascular health will be performed after 1 year.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - T6
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    7 days - 50 days
    Healthy volunteers
    No
    C1-T6
    Additionally, participants must
    NOT have an implanted devices such as brain, spine, or nerve stimulators, a cardiac pacemaker, defibrillator, or intra-cardiac lines

    What’s involved

    Type

    Technology

    Details

    - Participants will receive transcutaneous spinal stimulation (tSS) via the Neostim-5 system at regular intervals, beginning during inpatient rehabilitation and continuing through outpatient follow-up. - tSS is a non-invasive technique that uses surface electrodes to deliver electrical stimulation aimed at modifying spinal cord function. - During 20 to 29 sessions over the year, participants will receive tSS sitting upright and during tests where they are slowly tilted to assess blood pressure regulation. - Final testing of cardiovascular health will be performed after 1 year.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2025
    • Organisation
    • Kessler Foundation
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2025
    • Organisation
    • Kessler Foundation

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more