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Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury

Drug
Arm/hand function
Online since 19 March 2025, updated 266 days ago
Curated trial

About this trial

This trial is enrolling 55 individuals with acute traumatic spinal cord injury to test the effect of early oral baclofen treatment on functional recovery. If included, participants will either receive baclofen as soon as any signs of spasticity appear, or usual care, where baclofen is started only when spasticity becomes severe and problematic. Final testing will be performed at 6 months after the injury.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - L1
  • Severity (AIS)?
    • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≤ 1 month
  • Injury type

    • Traumatic

    Healthy volunteers
    No
    C1-L1
    Additionally, participants must
    NOT have pre-existing neurological disorders (cerebrovascular disease, Parkinson's disease, multiple sclerosis, etc.)
    NOT have a penetrating traumatic SCI

    What’s involved

    Type

    Drug

    Details

    - Participants will receive baclofen either as soon as any signs of spasticity appear, with the dosage adjusted weekly to achieve an optimal response, or usual care, where baclofen is started only when spasticity becomes severe and problematic. - Final testing will be performed at 6 months after the injury.

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    Bladder health/function

    General health

    Pain

    Sensory function

    Spasticity

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Dec 2024
    • Organisation
    • Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
    View on clinicaltrials.gov
    for more details
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Dec 2024
    • Organisation
    • Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
    View on clinicaltrials.gov
    for more details

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

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