Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI

Technology
General health
Online since 26 April 2025, updated today

About this trial

This trial is enrolling 44 participants with spinal cord injury to test the effect of stimulating a nerve (vagus which regulates various involuntary, automatic body functions) on inflammation and depression. The nerve stimulation will be delivered to the skin of the ear (called transcutaneous auricular vagus nerve stimulation -taVNS). If included, participants will be randomly assigned to receive either active taVNS or sham stimulation for 4 hours daily over a 30-day period. Final testing for safety and for measures of inflammation and depression will be performed after 30 days.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    All
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have a pacemaker or other implanted electrical device (e.g. cochlear implant, implanted vagus nerve stimulator, cardiac pacemaker)
    have mild to moderate measures for depression

    What’s involved

    Type

    Technology

    Details

    - Participants will be randomly assigned to receive either active transcutaneous auricular vagus nerve stimulation (taVNS) or sham stimulation for 4 hours daily over a 30-day period. - taVNS is a technique for stimulating the vagus nerve via surface stimulation on the skin of the ear to influence neural activity. - Final testing will be performed after 30 days.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Mental health and psychosocial factors

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 27 Jan 2025
    • Organisation
    • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 27 Jan 2025
    • Organisation
    • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more