Hemodynamic Management Following Acute Traumatic Spinal Cord Injury

Drug

General health

Online since 16 December 2024, updated 45 days ago

About this trial

This study is enrolling 228 participants with acute traumatic spinal cord injury to test the effect of different hemodynamic management strategies on general health. Hemodynamic management involves controlling blood flow and blood pressure to ensure that vital organs, including the brain and spinal cord, receive adequate blood supply. If included, participants will receive one of three hemodynamic management strategies during the first 5 days after injury: maintaining a higher blood pressure (85-90 mmHg); ensuring adequate blood flow to the spinal cord (≥65 mmHg); or keeping blood pressure at a normal level (≥65 mmHg). Final testing for motor scores and mobility will be performed after 12 months.

Included participants

Gender

All

Age

≥ 18 years

Injury level

C1 - L1

Severity (AIS)?

Time since injury

≤ 5 days

Injury type

Traumatic

Healthy volunteers

C1-L1

Additionally, participants must

NOT have a severe traumatic brain injury

NOT have an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection)

What’s involved

Type

Drug

Details

- Participants will receive one of three hemodynamic management strategies: maintaining a higher blood pressure (85-90 mmHg), ensuring adequate blood flow to the spinal cord (≥65 mmHg), or keeping blood pressure at a normal level (≥65 mmHg). - Hemodynamic management involves controlling blood flow and blood pressure to ensure that vital organs, such as the brain and spinal cord, receive adequate blood supply. - Final testing will be performed after 12 months.

Potential benefits

Main benefits

General health

Additional benefits

Arm/hand function

Bladder health/function

Bowel health

Sensory function

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

Wings for Life supports SCITrialsFinder

Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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