Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia

Surgery
General health
Online since 8 October 2024, updated 73 days ago

About this trial

This trial is enrolling 200 participants with spinal arachnoiditis and syringomyelia related to spinal cord injury or other infection. The study will compare the effect of two treatment procedures: a Subarachnoid-Subarachnoid (S-S) bypass, which creates a new pathway for cerebrospinal fluid to flow when the natural flow is obstructed; or an intradural adhesion lysis, a surgery that removes or releases scar tissue within the dura mater, the tough outer layer membrane around the cord. Both procedures address symptoms related to abnormal spinal fluid dynamics and spinal cord compression. If included, participants will receive either the S-S bypass or intradural adhesion lysis. Assessment of patient outcomes, complications, and quality of life will be performed after 3-6 months, 12 months and 24 months.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    All
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    Have a syringomyelia documented with MRI

    What’s involved

    Type

    Surgery

    Details

    - Participants will receive either the Subarachnoid-Subarachnoid (S-S) Bypass or intradural adhesion lysis. - An S-S Bypass is a procedure designed to create a new pathway for cerebrospinal fluid to flow when the natural flow is obstructed. - An intradural adhesion lysis is a surgery aims to remove or release scar tissue within the dura mater, which is the tough outer layer that surrounds the spinal cord. - Following the procedure assessments will be made at 3-6 months, 12 months, and 24 months. - Final assessment of complications and quality of life will be performed after 24 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2024
    • Organisation
    • Xuanwu Hospital, Beijing
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2024
    • Organisation
    • Xuanwu Hospital, Beijing

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more