Transdermal Administration by a Novel Wireless Iontophoresis Device

Drug

Bowel health

Online since 7 October 2024, updated 225 days ago

About this trial

This pilot study is enrolling 6 individuals with spinal cord injury to test the effect of a novel skin-surface device to deliver neostigmine and glycopyrrolate to improve bowel evacuation. This device allows for the medications to be administered through the skin and into the blood by applying an undetectable electrical current (a process called iontophoresis) rather than using needle injections. If included, participants will receive the 2 medications (neostigmine and glycopyrrolate) transdermally using the wireless ION device during 3 separate sessions. Final testing of bowel health will be performed after 3 days.

Included participants

Gender

All

Age

18 - 89 years

Injury level

C1 - S5

Severity (AIS)?

Time since injury

All

Healthy volunteers

Yes

C1-S5

Additionally, participants must

NOT have a deep brain stimulation device

NOT have a history of bowel or bladder obstruction

NOT have a history of heart conditions including coronary artery disease, myocardial infarctions, or arrhythmias

What’s involved

Type

Drug

Details

- Participants will receive 2 medications (neostigmine and glycopyrrolate) transdermally using the wireless ION device in 3 separate sessions. - This allows for the medication to be administered through the skin and into the circulation of the body by applying an undetectable electrical current rather than intravenously or intramuscularly. - Final testing of bowel evacuation will be performed after 3 days.

Potential benefits

Main benefits

Bowel health

Additional benefits

General health

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

Wings for Life supports SCITrialsFinder

Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

Learn more

Back to results