Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
About this trial
This study focuses on understanding how transcutaneous spinal stimulation can help people with muscle spasms and stiffness because of a spinal cord injury. When someone has a spinal cord injury, it ca...
Included participants
What’s involved
Type
Details
The primary questions to be addressed are whether the intervention reduces muscle stiffness and spasms and alters spinal reflexes: Using a 100-Hz (a measure of frequency) transcutaneous spinal stimulation is better than using a 50-Hz. Transcutaneous spinal stimulation at 50 Hz differs from a single dose of baclofen. Transcutaneous spinal stimulation at 50 Hz differs from a single dose of tizanidine. Combining the 50 Hz stimulation with either baclofen or tizanidine decreases spasticity more than just taking the medicine alone. Participants will visit the Methodist Rehabilitation Center in Jackson, Mississippi, six times over a period of 3 to 5 weeks. During the first visit, the overall health and motor and sensory functions will be assessed following a spinal cord injury. For the next five visits, participants will take a study medication (tizanidine, baclofen, or a placebo). After an hour, they will receive a continuous 30-minute transcutaneous spinal stimulation at either 50 Hz, 100 Hz, or sham. The spinal reflexes and clinical assessments will be evaluated before, during, and after each intervention.
Potential benefits
Main benefits
Spasticity
Additional benefits
General health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting soon
- Trial start date
- 1 Apr 2024
- Organisation
- University of Mississippi Medical Center
- Trial recruitment status
- Recruiting soon
- Trial start date
- 1 Apr 2024
- Organisation
- University of Mississippi Medical Center
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more