Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

About this trial

This trial is enrolling 60 individuals with chronic spinal cord injury between T2 and T10 to test the effect of spinal cord stimulation, both epidural (ESS) and transcutaneous (TSS), on lower limb function. Spinal cord stimulation is a technique using either implanted electrodes placed next to the spinal cord (ESS) or skin-surface electrodes (TSS) to stimulate the spinal cord and modify its function. If included, participants will undergo either: 1) surgery for implantation of the ESS device followed by ESS stimulation; 2) TSS stimulation; or 3) sham stimulation. Final testing of lower limb function, neurological status, and independence will be performed after 16 weeks.