Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal

Technology

Standing/walking/mobility

Online since 20 November 2023, updated 240 days ago

About this trial

This trial is enrolling 10 individuals with chronic spinal cord injuries (12 months or longer) to test the effect of non-invasive electrical and magnetic neuromodulation on mobility. Neuromodulation is the alteration of nerve activity through the targeted delivery of a stimulus. If included, participants will receive closed-loop skin-surface (transcutaneous) spinal cord stimulation via the RISES-T System (stimulation device, wearable sensors, and recording software) while completing repetitive task practice. Participants will also undergo a series of targeted tasks with and without electromagnetic stimulation. Final testing for movement recovery will be performed after 24 weeks.

Included participants

Gender

All

Age

≥ 18 years

Injury level

C1 - S5

Severity (AIS)?

AIS-A

AIS-B

AIS-C

AIS-D

Time since injury

≥ 12 months

Healthy volunteers

C1-S5

Additionally, participants must

NOT have uncontrolled cardiopulmonary disease or cardiac symptoms

NOT require ventilator support

NOT have any active implanted medical device

What’s involved

Type

Technology

Details

- Participants will receive closed-loop transcutaneous spinal cord stimulation while completing repetitive task practice. - Part 1 of the trial aims to determine which of the participant's muscles respond to stimulation and what stimulation parameters would be best suited for the participant. - During Part 2 of the trial, participants will receive transcutaneous stimulation to the target muscles identified in Part 1, using the parameters deemed best suited for the participant. - The participant will continue in the study for a maximum of 6 stimulation cycles or until there is no observed effect of stimulation for 3 consecutive cycles. - Final testing will be performed after 24 weeks.

Potential benefits

Main benefits

Standing/walking/mobility

Additional benefits

Pain

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

Wings for Life supports SCITrialsFinder

Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

Learn more

Back to results