Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury

Drug
Arm/hand function
Online since 30 September 2024, updated 22 days ago

About this trial

This trial is enrolling 40 individuals with chronic spinal cord injury to test feasibility and effect of a circulatory manipulation technique that alternately reduces blood flow and then allows normal blood flow (ischemic preconditioning - IPC) on upper limb exercise performance. IPC uses a blood pressure cuff on the arm , repeatedly inflated and deflated. If included, participants will be randomly assigned to receive either: four cycles of IPC (5 min cuff inflation followed by a 5 min period of cuff deflation); or sham intervention. Final testing of upper limb exercise performance will be performed after 40 minutes.

Included participants

Gender
All
Age
18 - 70 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 1 year
    Healthy volunteers
    No
    C1-S5

    What’s involved

    Type

    Drug

    Details

    - participants will be randomized to receive four cycles of IPC (5 min period of cuff inflation followed by a 5 min period of cuff deflation) or sham intervention. - final testing of upper limb exercise performance will be performed after 40 minutes.

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    General health

    Mechanism of action

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Nov 2023
    • Organisation
    • Loughborough University
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Nov 2023
    • Organisation
    • Loughborough University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more