Neurostimulation for Respiratory Function After Spinal Cord Injury

Technology
General health
Online since 12 March 2024, updated 35 days ago

About this trial

This trial is enrolling individuals with chronic cervical spinal cord injuries to test the effect of non-invasive spinal cord electrical stimulation and respiratory exercise training. The stimulation will be applied to the spinal cord and to peripheral nerves (nerves in the body outside the brain and spinal cord) so that the signals are received at specific intervals. This so-called spike-timing-dependent plasticity (STDP) may promote recovery breathing and cardiopulmonary fitness. If included, participants will undergo 40 sessions of stimulation over the scalp and neck, followed by about 60 minutes of respiratory training. Assessment sessions will be completed before the intervention, after 20 sessions and after 40 sessions, 14 weeks total participation.

Included participants

Gender
All
Age
18 - 85 years
Injury level
C1 - C5
  • Severity (AIS)?
  • Time since injury
    ≥ 6 months
    Healthy volunteers
    No
    C1-C5
    Additionally, participants must
    have respiratory deficits requiring ventilator use or demonstrate reduced vital capacity (less than 80%)
    Have a caregiver or family member who is trained and willing to operate the ventilator during study visits
    NOT be completely dependent on the support of a diaphragmatic pacer (24 hours per day)

    What’s involved

    Type

    Technology

    Details

    - participants will undergo 40 sessions of stimulation over the scalp and neck, followed by about 60 minutes of respiratory training. - Assessment sessions will be completed before the intervention, after 20 sessions and after 40 sessions.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 28 Feb 2023
    • Organisation
    • Shirley Ryan AbilityLab
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 28 Feb 2023
    • Organisation
    • Shirley Ryan AbilityLab

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more