Cord Blood Cells in Patients With Acute SCI

Biological/cell based
General health
Online since 12 March 2024, updated 35 days ago

About this trial

This trial is enrolling individuals with acute spinal cord injury (up to 7 days post injury) to test the safety and efficacy of the administration of umbilical cord blood cells. If included, participants will receive either: 4 infusions of allogenic cord blood cells samples within a 1-week interval; or 4 infusions of sterile saline (control). Final testing of safety and neurological outcomes will be performed after 12 months.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - L5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    ≤ 7 days
    Healthy volunteers
    No
    C1-L5
    Additionally, participants must
    have had decompressive, stabilizing surgery within 5 days post-SCI and prior to the first cell infusion
    NOT have motor function in lower limbs

    What’s involved

    Type

    Biological/cell based

    Details

    - participants will receive 4 infusions of allogenic non-related group- and rhesus-compatible mononuclear cord blood cells samples with a 1-week interval. - Final testing of safety and neurological outcomes will be performed after 12 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health/function

    Mental health and psychosocial factors

    Pain

    Sensory function

    Spasticity

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 5 Dec 2022
    • Organisation
    • Sklifosovsky Institute of Emergency Care
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 5 Dec 2022
    • Organisation
    • Sklifosovsky Institute of Emergency Care

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more