Cord Blood Cells in Patients With Acute SCI

Biological/cell based

General health

Online since 12 March 2024, updated 126 days ago

About this trial

This trial is enrolling individuals with acute spinal cord injury (up to 7 days post injury) to test the safety and efficacy of the administration of umbilical cord blood cells. If included, participants will receive either: 4 infusions of allogenic cord blood cells samples within a 1-week interval; or 4 infusions of sterile saline (control). Final testing of safety and neurological outcomes will be performed after 12 months.

Included participants

Gender

All

Age

18 - 75 years

Injury level

C1 - L5

Severity (AIS)?

AIS-A

AIS-B

Time since injury

≤ 7 days

Healthy volunteers

C1-L5

Additionally, participants must

have had decompressive, stabilizing surgery within 5 days post-SCI and prior to the first cell infusion

NOT have motor function in lower limbs

What’s involved

Type

Biological/cell based

Details

- participants will receive 4 infusions of allogenic non-related group- and rhesus-compatible mononuclear cord blood cells samples with a 1-week interval. - Final testing of safety and neurological outcomes will be performed after 12 months.

Potential benefits

Main benefits

General health

Additional benefits

Arm/hand function

Bladder health/function

Mental health and psychosocial factors

Pain

Sensory function

Spasticity

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

Wings for Life supports SCITrialsFinder

Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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