NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

Drug
General health
Online since 16 August 2023, updated 244 days ago

About this trial

This trial is enrolling individuals with chronic spinal cord injury to test the safety and effects of using a short-acting drug (Glyceryl trinitrate) to reduce blood pressure during dangerous blood pressure spikes (autonomic dysreflexia) that can happen during bowel care. If included, participants will receive either: 1) the active drug administered via sublingual spray (0.4 mg) up to three times every 15 minutes; or 2) placebo sublingual spray. Blood pressure testing will be performed during bowel care on two occasions within 28 days, each for up to an hour.

Included participants

Gender
All
Age
19 - 80 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    ≥ 1 year
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    Have known incidence of autonomic dysreflexia.

    What’s involved

    Type

    Drug

    Details

    - Participants will either receive 1) the active drug administered via sublingual spray (0.4 mg) up to three times every fifteen minutes or 2) placebo sublingual spray. - Blood pressure testing will be performed during bowel care.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Sep 2023
    • Organisation
    • Simon Fraser University
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Sep 2023
    • Organisation
    • Simon Fraser University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more