Effects of CB1 Antagonist/Reverse Agonist Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury

Drug
General health
Online since 23 August 2023, updated 180 days ago

About this trial

This trial is enrolling individuals with chronic incomplete spinal cord injuries between C4 and L1 to test the safety of a drug (Rimonabant) and its potential effect on walking ability. If included, participants will either take: 1) Rimonabant 5mg per day for 90 days; or 2) a placebo drug for 90 days. Final testing of walking ability will be performed after 90 days; other safety measures will be assessed after 120 days.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C4 - L1
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    ≥ 1 year
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C4-L1
    Additionally, participants must
    NOT have severe bone, kidney, or liver dysfunction
    NOT have hypothyroidism

    What’s involved

    Type

    Drug

    Details

    - participants will either take 1) Rimonabant 5mg per day for 90 days or 2) a placebo for 90 days. - Final testing of walking ability will be performed after 90 days - Final safety measures will be assessed after 120 days including e.g., adverse events, urine samples, ECG, and questionnaires.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Mental health

    Pain

    Sensory function

    Spasticity

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Nov 2022
    • Organisation
    • Hospital Nacional de Parapléjicos de Toledo
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Nov 2022
    • Organisation
    • Hospital Nacional de Parapléjicos de Toledo

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more