Effects of Intermittent Hypoxia in Upper and Lower Limb Functions in Persons With Incomplete Spinal Cord Injury

Drug
Arm/hand function
Online since 12 March 2024, updated 27 days ago

About this trial

This trial is enrolling individuals with incomplete spinal cord injuries for at least 3 months (at level C4 or below) to test the effect of acute intermittent hypoxia (AIH) on upper and lower limb function. AIH involves repeatedly breathing air with low oxygen content for brief periods, alternating with breathing room air with normal oxygen content. If included, participants will undergo an intervention 3 times/week for a period of 4 weeks of either: 1) AIH (9% oxygen) alternating with normal air (21% oxygen); or 2) a sham treatment, normal air alternating with normal air. Assessments include upper and lower limb motor function, balance, quality of life, and disability.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C4 - S5
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    ≥ 3 months
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C4-S5

    What’s involved

    Type

    Drug

    Details

    -Participants will undergo either 1) an AIH intervention or 2) a sham intervention 3 times/week for a period of 4 weeks - Final testing of upper and lower limb function will be performed 30 days after the intervention

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    Mental health

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • Riphah International University
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • Riphah International University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more