Effects of 4-AP on Functional SCI Recovery

About this trial

This trial is enrolling individuals spinal cord injuries for at least 4 weeks to test the effect a drug (Dalfampridine, 4-AP) in combination with spike timing dependent plasticity (STDP) stimulation and lower limb training on walking and other aspects of spinal cord function, including electrical measures of nerve conduction. STDP is a technique that applies paired electrical stimulation to the spinal cord and peripheral nerves. If included, participants will receive either: 1) 4-AP + STDP + training for 10 sessions; or 2) a placebo drug + STDP + training for 10 session. Following these sessions, participants in either arm of the study may be eligible for inclusion in an additional period of treatment with 4-AP + STDP + training for 40 sessions.