Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury

About this trial

This trial is enrolling 4 individuals with chronic cervical (neck area) or high thoracic (chest area) spinal cord injuries to test the effect of an implanted electrical stimulation device (Targeted Epidural Spinal Stimulation - TESS) on blood pressure stability. The research team wants to see if spinal cord stimulation can reduce the incidence and severity of orthostatic hypotension (low blood pressure) and autonomic dysreflexia (sudden high blood pressure). If included, the participant will be assessed before and after the device is implanted. After a month to customize the device to the individual, two weeks of supervised at-home use with additional scheduled laboratory TESS and assessment sessions for 25 weeks. The study will measure the long-term safety and effect of spinal cord stimulation on cardiovascular health, respiratory function, and quality of life.