Autologous Adipose Derived Mesenchymal Stem Cells for Spinal Cord Injury Patients

Biological/cell based
General health
Online since 5 November 2021, updated 837 days ago

About this trial

This is a clinical trial to investigate the safety and effect of a stem cell intervention in individuals with traumatic spinal cord injury. The cells used are a type of stem cell (mesenchymal) processed from the participant's own fat (adipose) tissue. The cells are removed from fat tissue, expanded, and then injected back into the fluid surrounding the spinal cord. Participants will undergo follow-up measurement for up to 2 years, including testing for motor, sensory and other neurological functions, including bladder and bowel function. If included in the sudy, participants will be randomly assigned to one of two study groups: 1) receiving the stem cell injection; or 2) receiving the stem cell injection after six months of standard medical management, including occupational and physical therapy.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    ≥ 6 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have infectious disease, including tuberculosis, HIV, hepatitis, and syphilis
    be able to undergo MRI scan

    What’s involved

    Type

    Biological/cell based

    Details

    Harvesting of adipose (fat) tissue-derived mesenchymal stem cells from the participant's body A single injection into the fluid surrounding the spinal cord Potentially physical and occupational therapy for six months Follow-up measurements on motor and sensory function up to 24 months post treatment

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health

    Bowel health

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 25 Jun 2020
    • Organisation
    • Mayo Clinic
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 25 Jun 2020
    • Organisation
    • Mayo Clinic

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more