Physiological Changes Induced Through MEP Conditioning in People With SCI
About this trial
This is a clinical trial enrolling individuals with incomplete spinal cord injuries to assess the effects of magnetic brain stimulation on walking function. SCI damages important movement controls from the brain to the spinal cord to the target muscles. Transcranial magnetic stimulation (TMS) is a non-invasive technique which provides a magnetic field by way of a coil held over the head to activate nerves, thus strengthening the brain-spinal cord-muscle pathways. This study will compare the effect of TMS alone to TMS plus standard physical therapy training. If selected for the trial, participants will be randomly assigned to one of two study groups: 1) performing movement tasks (such as standing, sitting and walking) and receiving TMS; or 2) receiving TMS only. Motor connections and activity of brain-spinal cord-muscle pathways will be assessed with electrodes placed on the skin over leg muscles to monitor muscle activity. Researchers will also measure changes in walking function. There will be three training sessions per week for four months, followed by two to three sessions over another three months.
Included participants
Traumatic
What’s involved
Type
Details
Approximately three sessions per week for four months Followed by two to three sessions over another three months Each session lasts approximately 1 hour
Potential benefits
Main benefits
Standing/walking/mobility
Additional benefits
General health
Mechanism of action
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting
- Trial start date
- 22 Feb 2021
- Organisation
- Medical University of South Carolina
- Trial recruitment status
- Recruiting
- Trial start date
- 22 Feb 2021
- Organisation
- Medical University of South Carolina
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more