High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.

Drug
General health
Online since 2 January 2024, updated 59 days ago

About this trial

This is a trial to test the effect of a drug (4-Aminopyridine) on motor function, sensation, bowel and bladder function, quality of life, independence, and erectile dysfunction after spinal cord injury. If included in this trial, the participant will receive two capsules 3 times a day after meals of either 1) the active drug or 2) An inactive placebo. Final testing will be performed 6 months after the intervention.

Included participants

Gender
All
Age
18 - 60 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-A
    Time since injury
    2 years - 60 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C4-T12
    Additionally, participants must
    have a spinal cord injury for at least 2 years.
    have a neurological level of injury between C4 and T12.
    have an ASIA impairment scale of AIS A: complete; no feeling or movement below the injury.

    What’s involved

    Type

    Drug

    Details

    The participant will receive two capsules 3 times a day after meals of either 1) the active drug or 2) An inactive placebo. Final testing of motor function, sensation, bowel and bladder function, quality of life, independence, and erectile dysfunction 6 months after the intervention.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health

    Bowel health

    Mental health

    Sensory function

    Sexual health

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Unknown
    • Trial start date
    • 17 Jul 2019
    • Organisation
    • Coordinación de Investigación en Salud, Mexico
    • Trial recruitment status
    • Unknown
    • Trial start date
    • 17 Jul 2019
    • Organisation
    • Coordinación de Investigación en Salud, Mexico

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more