High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.

Drug

General health

Online since 2 January 2024, updated 196 days ago

About this trial

This is a trial to test the effect of a drug (4-Aminopyridine) on motor function, sensation, bowel and bladder function, quality of life, independence, and erectile dysfunction after spinal cord injury. If included in this trial, the participant will receive two capsules 3 times a day after meals of either 1) the active drug or 2) An inactive placebo. Final testing will be performed 6 months after the intervention.

Included participants

Gender

All

Age

18 - 60 years

Injury level

C4 - T12

Severity (AIS)?

AIS-A

Time since injury

2 years - 60 years

Injury type

Traumatic

Healthy volunteers

C4-T12

Additionally, participants must

have a spinal cord injury for at least 2 years.

have a neurological level of injury between C4 and T12.

have an ASIA impairment scale of AIS A: complete; no feeling or movement below the injury.

What’s involved

Type

Drug

Details

The participant will receive two capsules 3 times a day after meals of either 1) the active drug or 2) An inactive placebo. Final testing of motor function, sensation, bowel and bladder function, quality of life, independence, and erectile dysfunction 6 months after the intervention.

Potential benefits

Main benefits

General health

Additional benefits

Arm/hand function

Bladder health/function

Bowel health

Mental health and psychosocial factors

Sensory function

Sexual health

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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