Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI
About this trial
This trial is recruiting individuals with chronic incomplete spinal cord injuries to test the safety and effect of acute intermittent hypoxia (AIH) on hand and finger function. AIH involves repeatedly breathing air with reduced oxygen content for brief periods, alternating with room air and normal oxygen content. Researchers want to see if these short durations of reduced oxygen promote new nerve connections in the damaged spinal cord. This trial will study the most appropriate timing of AIH sessions. Participants will be assigned to one of four groups to receive either a single or two sessions of AIH, or a single or two sessions of normal room air only (control group; sham AIH). Participants will wear a mask and will not know the oxygen content of breathed air. Breathing sessions are 15 cycles of 1.5 minutes each. The effects of AIH will be measured by changes in upper extremity function (hand grip and pinch strength, the 9-hole peg test, etc).
Included participants
Traumatic
Non-traumatic
What’s involved
Type
Details
Single AIH or sham AIH session includes breathing 15 cycles of 1.5 min low and normal oxygen levels for a total of 45 minutes. Two AIH or sham AIH sessions including breathing 15, 1.5 minute cycles of low and normal oxygen levels for a total of 45 minutes per session. During the sessions, a mask will be worn to breathe air with different oxygen contents. Upper extremity function (hand and arm) will be tested before and after each training session.
Potential benefits
Main benefits
Arm/hand function
Additional benefits
General health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Recruitment
- Unknown
- Trial start date
- 1 May 2016
- Organisation
- Shirley Ryan AbilityLab
- Recruitment
- Unknown
- Trial start date
- 1 May 2016
- Organisation
- Shirley Ryan AbilityLab
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more