Non-Invasive Stimulation for Improving Motor Function

Technology
Standing/walking/mobility
Online since 2 January 2024, updated 170 days ago

About this trial

This is a phase 2 trial to test the effect of non-invasive brain stimulation when combined with peripheral nerve stimulation on motor recovery in the legs after incomplete spinal cord injury. The stimulation consists of a non-invasive technique which uses a magnetic field to stimulate the brain through a coil (held over the head) to activate pathways between the brain and spinal cord. The project is testing what are the best pairing times for brain stimulation (0ms, 20ms, or 50ms) prior to non-invasive peripheral nerve stimulation to the skin surface of the leg(s). If included in this trial, the participant will receive all 3 stimulus-pairing protocols.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    6 months - 80 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    have had a traumatic SCI for at least 6 months.
    have a neurological level of injury between C1-S5.
    have one of the following ASIA impairment scale (AIS):

    What’s involved

    Type

    Technology

    Details

    - 3 sessions of different stimulus pairing protocols (each session is 15 minutes in duration). - Neurological, reflex and walking tests and clinical examinations before the first session and after the last session.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Arm/hand function

    General health

    Mechanism of action

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Jul 2013
    • Organisation
    • Burke Medical Research Institute
    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Jul 2013
    • Organisation
    • Burke Medical Research Institute

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more