Non-invasive Cervical Electrical Stimulation for SCI

Technology
Arm/hand function
Online since 3 November 2021, updated 888 days ago

About this trial

This trial is recruiting individuals with chronic cervical (neck area) spinal cord injuries to test the effect of cervical electrical stimulation (CES) on hand function. The stimulation is non-invasive — skin-surface electrodes are placed on the neck. The goal of the study is strengthen preserved nerve circuits to hand muscles, a top priority for individuals with cervical SCI. In this two-part study, CES will first be applied in combination with transcranial magnetic stimulation (non-invasive surface stimulation of the brain) and peripheral nerve stimulation (non-invasive electrical stimulation of nerves in the upper extremities). Information derived from these initial stimulations will determine the CES settings for each participant. Active rehabilitation of hands and wrists will also be included to enhance voluntary muscle activation. This study may lead to the clinical use of CES to improve the effects of physical exercise.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C2 - C8
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    12 months - 75 years
  • Injury type
  • Traumatic

    Healthy volunteers
    Yes
    C2-C8
    Additionally, participants must
    NOT be dependent on a ventilator
    NOT have other implanted device, e.g. pacemaker

    What’s involved

    Type

    Technology

    Details

    Attachment of stimulation electrodes at the skin surface of the neck Attachment of recording electrodes at the skin surface of the upper extremity CES combined with transcranial magnetic stimulation or peripheral nerve stimulation at rest CES while performing hand and wrist movements The participant will complete the various stimulation, movement activities and outcome assessments in a single visit to the study center.

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 22 Aug 2017
    • Organisation
    • Bronx VA Medical Center
    • Trial recruitment status
    • Ended
    • Trial start date
    • 22 Aug 2017
    • Organisation
    • Bronx VA Medical Center

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more