Enhancing Corticospinal Excitability to Improve Functional Recovery

Technology
Arm/hand function
Online since 10 July 2024, updated 5 days ago

About this trial

This trial is enrolling individuals with cervical (neck area) spinal cord injuries to test different types of non-invasive transcranial direct current stimulation (tDCS) applied to the scalp. Researchers theorize that increasing brain activity using tDCS stimulation might improve brain response (excitability) and thus improve hand function. Four different stimulation approaches and one sham (inactive) control stimulation will be used to find the optimal stimulation method. Participants will do five 30-minute sessions over 5 weeks with each type of stimulation. Participants will also complete a questionnaire to evaluate their perceptions of the stimulation effects. Before and after each stimulation session, changes in muscle control and strength in the hands will be measured, as well as any changes in physiological measures of brain activity or excitability.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C1 - C8
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 6 months
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-C8
    Additionally, participants must
    have at least a visible voluntary twitch in the thumb or index finger on both arms.
    NOT have pain or hypersensitivity of the arm/hand that would limit participation
    NOT have another implanted device, e.g. pacemaker

    What’s involved

    Type

    Technology

    Details

    Five 30-minute non-invasive brain stimulation sessions over 5 weeks.

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 3 May 2018
    • Organisation
    • Shepherd Center, Atlanta GA
    • Trial recruitment status
    • Ended
    • Trial start date
    • 3 May 2018
    • Organisation
    • Shepherd Center, Atlanta GA

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more