Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition

Drug

Spasticity

Online since 8 September 2023, updated 529 days ago

About this trial

The trial is enrolling 90 individuals with chronic cervical or thoracic spinal cord injuries to test the effect of a drug, Riluzole, on spasticity. If included, participants will receive either: 1) four varying doses of Riluzole; or 2) a placebo drug. Final testing of blood samples to determine effective dosing of Riluzole will be performed after 2 months.

Included participants

Gender

All

Age

18 - 65 years

Injury level

C4 - T12

Severity (AIS)?

AIS-A

AIS-B

AIS-C

AIS-D

Time since injury

12 months - 65 years

Injury type

Traumatic

Healthy volunteers

C4-T12

Additionally, participants must

present with spasticity

What’s involved

Type

Drug

Details

Participants will receive either - 1) four doses of the active drug (Riluzole) or - 2) the placebo drug. - Final testing of blood samples will be performed after 2 months.

Potential benefits

Main benefits

Spasticity

Additional benefits

General health

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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