AIH-induced Walking Recovery After Subacute SCI

Drug
Standing/walking/mobility
Online since 8 November 2021, updated 834 days ago

About this trial

This trial is recruiting individuals with recent spinal cord injuries to test the effect on walking function of breathing air with low oxygen alternated with room air/normal oxygen (acute intermittent hypoxia, AIH). Participants will receive 10 sessions over two weeks of AIH or room air through a face mask. Those who are ambulatory will receive 60 minutes of walking practice after the delivery of AIH or normal oxygen. Neither participants nor investigators will know which type of air (AIH or normal) is administered. Primary assessments include changes in walking recovery. Pain and spasticity will also be measured.

Included participants

Gender
All
Age
18 - 70 years
Injury level
C4 - T11
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    2 months - 6 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C4-T11

    What’s involved

    Type

    Drug

    Details

    10 sessions (5 days each week for 2 weeks) 1) AIH or 2) normal oxygen through a face mask. If ambulatory, the participant will receive 10 walking practice sessions (5 days each week for 2 weeks after AIH, normal oxygen or walking practice only.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Arm/hand function

    General health

    Mental health

    Pain

    Spasticity

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Active
    • Trial start date
    • 1 Oct 2015
    • Organisation
    • Spaulding Rehabilitation Hospital
    • Trial recruitment status
    • Active
    • Trial start date
    • 1 Oct 2015
    • Organisation
    • Spaulding Rehabilitation Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more