AIH-induced Walking Recovery After Subacute SCI

Drug

Standing/walking/mobility

Online since 8 November 2021, updated 1139 days ago

About this trial

This trial is recruiting individuals with recent spinal cord injuries to test the effect on walking function of breathing air with low oxygen alternated with room air/normal oxygen (acute intermittent hypoxia, AIH). Participants will receive 10 sessions over two weeks of AIH or room air through a face mask. Those who are ambulatory will receive 60 minutes of walking practice after the delivery of AIH or normal oxygen. Neither participants nor investigators will know which type of air (AIH or normal) is administered. Primary assessments include changes in walking recovery. Pain and spasticity will also be measured.

Included participants

Gender

All

Age

18 - 70 years

Injury level

C4 - T11

Severity (AIS)?

AIS-A

AIS-B

AIS-C

AIS-D

Time since injury

2 months - 6 months

Injury type

Traumatic

Healthy volunteers

C4-T11

What’s involved

Type

Drug

Details

10 sessions (5 days each week for 2 weeks) 1) AIH or 2) normal oxygen through a face mask. If ambulatory, the participant will receive 10 walking practice sessions (5 days each week for 2 weeks after AIH, normal oxygen or walking practice only.

Potential benefits

Main benefits

Standing/walking/mobility

Additional benefits

Arm/hand function

General health

Mental health and psychosocial factors

Pain

Spasticity

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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