Corticospinal Function After Spinal Cord Injury
About this trial
This trial is recruiting individuals with cervical (neck area) spinal cord injuries to study nerve recovery in a spinal cord area called the corticospinal tract, important for upper and lower-limb motor function. There are two parts to the study (participants can enter one or both). The first part will measure electrical signals in the brain and the spinal cord. This allows the investigators to draw maps of the specific nerves activated when upper limb muscles are used. The study will focus on the movements and brain signals required for reaching and grasping. The second part will assess physical training of the upper limbs combined with a non-invasive brain stimulation (Transcranial Magnetic Stimulation, TMS). This involves 15 sessions. Participants will randomly be put in a group that either receives TMS and arm/hand training, or placebo (inactive) stimulation with arm/hand training. The focus will be on reach and grasp movements because of their importance in daily life activities.
Included participants
Traumatic
Non-traumatic
What’s involved
Type
Details
First part: The participant will complete an electrophysiology assessment involving simple movement tasks (for e.g., reaching for an object) in 2-4 sessions. Second part: The participant will partake in 15 TMS training sessions to apply a painless magnetic pulse to the head combined with exercise. The final visit will occur 5 months after the last session.
Potential benefits
Main benefits
Arm/hand function
Additional benefits
General health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting
- Trial start date
- 12 Oct 2020
- Organisation
- Shirley Ryan AbilityLab
- Trial recruitment status
- Recruiting
- Trial start date
- 12 Oct 2020
- Organisation
- Shirley Ryan AbilityLab
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more