Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

Drug
Standing/walking/mobility
Online since 31 May 2022, updated 29 days ago

About this trial

This trial is recruiting individuals with chronic incomplete spinal cord injuries to study how repeatedly breathing air with low oxygen (intermittent hypoxia therapy; IHT) enhances motor function and spinal plasticity (strengthening of nerve pathways). ITH will be done in combination with training to improve walking. Participants will breathe short periods of air with low oxygen through a face mask in combination with 30 minutes of walking training or 30 minutes of strength training only; each participant will receive both walking or strength training, but the investigator will not know the order of treatments. DNA will be taken from a saliva sample at the first visit and analyzed for a protein marker that may predict response to IHT. The study will measure walking endurance and muscle strength.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C2 - T11
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    1 year - 75 years
  • Injury type
  • Traumatic

    Non-traumatic

    Ischemia

    Healthy volunteers
    Yes
    C2-T11

    What’s involved

    Type

    Drug

    Details

    Repeatedly breathing short periods of air with low oxygen content (intermittent hypoxia) through a face mask in combination with: 30 minutes of walking training consisting of 5 repetitions of 6-minute walks or 30 minutes of strength training consisting of 3 sets of ankle movement exercises of 10 repetitions. DNA will be taken from a saliva sample at the first visit and analyzed for a protein that may predict if they will respond to intermittent hypoxia.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Recruitment
    • Unknown
    • Trial start date
    • 1 Oct 2014
    • Organisation
    • Spaulding Rehabilitation Hospital
    • Recruitment
    • Unknown
    • Trial start date
    • 1 Oct 2014
    • Organisation
    • Spaulding Rehabilitation Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more