| NCT01772810 | Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI | Neuralstem Inc. | | - Age 18 - 65 yrs
- Level C5-C7
AIS A- 1 years - 2 years
- live within 500 miles from University of California San Diego Medical Center
- NOT have penetrating injury, e.g. gunshot or knife wound
- NOT have received investigational drug or device within 30 days of stem cell operation
- NOT have implanted spine stimulator
| | 8 | PHASE1 | Biological/cell based | Standing/walking/mobility | - Adverse Events (AEs)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
| 60 months | 01 August 2014 | 21 January 2013 | 1 | |
| NCT01714349 | Nerve Transfer After Spinal Cord Injuries | Washington University School of Medicine | | - Age 18 - 65 yrs
- Level C1-C8
AIS A, B, C- 6 months - 48 months
- have no significant pain
- show minimal or no evidence of motor function improvement after 6 months post-injury
| Ended | 20 | NA | Surgery | Arm/hand function | | 48 months | 01 October 2012 | 25 October 2012 | 2 | |
| NCT01676441 | Safety and Efficacy of Autologous Mesenchymal Stem Cells in Chronic Spinal Cord Injury | Pharmicell Co., Ltd. | | - Age 16 - 65 yrs
- Level C1-C8
AIS B- ≥ 12 months
- NOT have undergone major surgery in past 3 months
- NOT be dependent on mechanical ventilator
- NOT have penetrating injury, e.g. gunshot or stab wound
- NOT have other implanted device, e.g. pacemaker
| Ended | 20 | PHASE2, PHASE3 | Biological/cell based | General health | - American Spinal Injury Association Impairment Scale (AIS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
| 12 months | 01 August 2008 | 31 August 2012 | 2 | |
| NCT01659541 | Stimulation With Wire Leads to Restore Cough | MetroHealth Medical Center | | - Age 18 - 75 yrs
- Level C1-C8
AIS A, B, C, D- ≥ 6 months
| Ended | 12 | NA | Technology | General health | | 1 year | 01 April 2015 | 08 August 2012 | 1 | |
| NCT01608438 | Motor Learning in a Customized Body-Machine Interface | Shirley Ryan AbilityLab | | - Age 18 - 65 yrs
- Level C3-C6
AIS A, B, C- ≥ 0 hours
- NOT have tremors or spasms
| | 157 | NA | Technology | Arm/hand function | - State-trait Anxiety Inventory (STAI)
| 8 months | 01 February 2013 | 31 May 2012 | 1 | |
| NCT01597518 | Riluzole in Spinal Cord Injury Study | AOSpine North America Research Network | | - Age 18 - 75 yrs
- Level C4-C8
AIS A, B, C- ≤ 12 hours
- NOT have had a previous spinal cord injury
- NOT have a penatrating injury, e.g. gunshot or stab
| Ended | 193 | PHASE2, PHASE3 | Drug | General health | - American Spinal Injury Association Impairment Scale (AIS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
| 180 days | 01 October 2013 | 14 May 2012 | 30 | |
