| NCT02574572 | Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury | Hospital Sao Rafael | | - Age 18 - 65 yrs
- Level C5-C7
AIS A- ≥ 12 months
- have a spinal cord injury for at least 12 months
- have a neurological level of injury between C5 and C7
- have the following ASIA impairment scale (AIS) grade:
- AIS A: complete; no feeling or movement below the injury
- be between 18 and 65 years of age
- NOT have penetrating injury, e.g. gunshot or knife wound
- NOT have other device implanted that would affect MRI, e.g. pacemaker
| | 10 | PHASE1 | Biological/cell based | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
| 12 months | 06 September 2017 | 14 October 2015 | 1 | |
| NCT02566850 | Investigational Study of the Ekso for High-Dosage Use by Individuals With SCI in a Non-Clinical Environment | Ekso Bionics | | - Age 18 - 65 yrs
- Level C1-S5
AIS A, B, C, D- All
- have a body height between 152 and 193cm (5’-6’33 feet)
- have a body weight of less than 100kg (<200 lbs)
- have a prior experience or be willing to train on the Ekso device with a minimum of 20 hours and no more than 50 hours of device use and require no greater than minimal assist (support of up to 25% body weight) for safe and consistent walking. Participants with more than 50 hours of device experience must agree to a 1 month period of non-use prior to acquisition of baseline measures
| Ended | 4 | NA | Rehabilitation | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Bowel and bladder control
- Spinal Cord Independence Measure (SCIM)
| 42 months | 01 January 2014 | 02 October 2015 | 1 | |
| NCT02564419 | Brain Machine Interface (BMI) in Subjects Living With Quadriplegia | University of Miami | | - Age 22 - 50 yrs
- Level C5-C6
AIS A, B- ≥ 6 months
| Ended | 1 | NA | Technology | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
| 2 years | 01 November 2015 | 30 September 2015 | 1 | |
| NCT02524379 | Spinal Cord Injury Neuroprotection With Glyburide | Ohio State University | | - Age 18 - 80 yrs
- Level C2-C8
AIS A, B, C- ≤ 8 hours
- NOT have penetrating injury, e.g. gunshot to knife wound
| Ended | 3 | PHASE1, PHASE2 | Drug | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Serum Biomarker
| 1 year | 14 February 2017 | 14 August 2015 | 1 | |
| NCT02495545 | Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury | St. Joseph's Hospital and Medical Center, Phoenix | | - Age 18 - 75 yrs
- Level C4-C8
AIS A, B, C- ≤ 24 hours
- NOT have penetrating injury, e.g. gunshot or knife wound
| Ended | 15 | NA | Surgery | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Pain Numeric Rating Scale (NRS)
- Spinal Cord Independence Measure (SCIM)
| 180 days | 01 October 2015 | 13 July 2015 | 3 | |
| NCT02490501 | Safety and Efficacy of SC0806 (Fibroblast Growth Factor 1 and a Device) in Traumatic Spinal Cord Injury Subjects | BioArctic AB | | - Age 18 - 65 yrs
- Level T2-T11
AIS A- 4 months - 10 years
- have a BMI of less than 35.
- have a body height of less than 195cm (<6’4 feet).
- have a body weight of less than 125kg (<275 lbs).
- be able to undergo and tolerate the MRI scanning.
- NOT have known hypersensitivity to FGF1 or heparin
| Ended | 10 | PHASE1, PHASE2 | Biological/cell based | Standing/walking/mobility | - Adverse Events (AEs)
- Motor Evoked Potentials (MEPs)
| 18 months | 01 June 2015 | 03 July 2015 | 1 | |
