Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study

Technology
Standing/walking/mobility
Online since 26 April 2026, updated today

About this trial

This trial is enrolling 10 participants with chronic non-traumatic spinal cord injury to test the effect of epidural spinal stimulation (eSS) combined with walking training on lower extremity function. eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will undergo surgical implantation of an eSS device followed by a structured rehabilitation program, including intensive standing and stepping training. Final testing of lower extremity function will be performed after 6 months.

Included participants

Gender
All
Age
≥ 18 years
Injury level
T1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 12 months
  • Injury type
  • Non-traumatic

    Healthy volunteers
    No
    T1-S5

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo surgical implantation of an epidural spinal stimulation (eSS) device followed by a structured rehabilitation program, including intensive standing and stepping training. - eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - Final testing of lower extremity function will be performed after 6 months.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Pain

    Spasticity

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Mar 2026
    • Organisation
    • IRCCS San Raffaele
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Mar 2026
    • Organisation
    • IRCCS San Raffaele

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more