Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation

About this trial

This trial is enrolling 40 participants with spinal cord injury and at least 6 months post injury, who use intermittent catheterization to test the effect of lactobacillus crispatus on bladder health. Lactobacillus crispatus is a type of beneficial bacteria that normally lives in healthy urinary and vaginal environments and can help prevent harmful bacteria from growing. If included, participants will be randomly assigned to undergo two overnight bladder instillations with either lactobacillus crispatus in saline or saline alone. The instillation will be administered directly into the bladder via catheter. Final assessment of bladder health will be performed after 23 days.