Effect of TMS on Neuropathic Pain for Patients With Sci

Technology
Pain
Online since 1 April 2026, updated 9 days ago

About this trial

This trial is enrolling 39 participants with chronic spinal cord injury and chronic central (neuropathic) pain to test the effect of repetitive transcranial magnetic stimulation (rTMS) on that pain. rTMS is a non-invasive technique which uses a magnetic field to stimulate the brain. An electric coil (held over the head) delivers magnetic pulses that activate parts of the brain underneath the coil. If included, participants will be randomly assigned to undergo 10 sessions over a 2-week period of either sham (inactive) or active rTMS, targeting either the primary motor cortex (a part of the brain which has been found previously to beneficially affect central pain) or the anterior cingulate cortex (another part which may also affect pain). Final testing for neuropathic pain will be performed after 12 weeks.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    ≥ 12 months
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have metallic implants in the scalp, cochlear implants, pacemaler or spinal cord stimulator
    Have central, neuropathic pain.

    What’s involved

    Type

    Technology

    Details

    - Participants will be randomly assigned to undergo 10 sessions of sham transcranial magnetic stimulation (rTMS) or active rTMS at 5 Hz targeting either the primary motor cortex or the anterior cingulate cortex over a 2-week period. - rTMS is a non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic pulses that activate parts of the brain directly under the coil. - Final testing for pain will be performed after 12 weeks.

    Potential benefits

    Main benefits

    Pain

    Additional benefits

    General health

    Mental health and psychosocial factors

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Dec 2025
    • Organisation
    • Ankara Etlik City Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Dec 2025
    • Organisation
    • Ankara Etlik City Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more