Duraplasty for Acute Traumatic Spinal Cord Injury

Surgery
General health
Online since 1 April 2026, updated 9 days ago

About this trial

This trial is enrolling 66 participants with very acute spinal cord injury during their initial acute hospital stay after spinal cord injury to compare the effect of expansile duraplasty with standard surgery alone. Expansile duraplasty is a surgical procedure in which the dura, the outermost membrane protecting the spinal cord, is opened and expanded with a patch to create more space for injured spinal cord swelling. If included, participants will be randomly assigned to receive standard spinal cord surgery either with or without duraplasty. Final testing of neurological function will be performed after 6 months.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C3 - C7
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≤ 24 null
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C3-C7

    What’s involved

    Type

    Surgery

    Details

    - Participants will be randomly assigned to receive standard spinal cord surgery either with or without duraplasty. - Expansile duraplasty is a surgical procedure in which the dura of the spinal cord is opened and expanded with a dural patch to create more space for the injured spinal cord. - Final testing of neurological function will be performed after 6 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health/function

    Bowel health

    Mental health and psychosocial factors

    Pain

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Mar 2026
    • Organisation
    • University of California, San Francisco
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Mar 2026
    • Organisation
    • University of California, San Francisco

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more