Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury
About this trial
This trial is enrolling 34 participants with very acute thoracic or lumbar spinal cord injury to test the effect of metformin on neurological recovery. Metformin is an orally administered drug commonly used to treat diabetes that has demonstrated neuroprotective effects. If included, participants will be randomly assigned to receive either metformin (1,000 mg twice daily) or a placebo. Final testing neurological recovery will be performed after 3 months.
Included participants
What’s involved
Type
Details
- Participants will be randomly assigned to receive either metformin (1,000 mg twice daily) or a placebo. - Metformin is an orally administered drug commonly used to treat diabetes that has demonstrated neuroprotective effects. - Final testing neurological recovery will be performed after 3 months.
Potential benefits
Main benefits
General health
Additional benefits
Arm/hand function
Pain
Sensory function
Standing/walking/mobility
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting soon
- Trial start date
- 1 Jan 2026
- Organisation
- Badr University
- Trial recruitment status
- Recruiting soon
- Trial start date
- 1 Jan 2026
- Organisation
- Badr University
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more